A1c 9.1 to 5.4 in fourteen months. Time-restricted eating, walking after meals, and dropping liquid sugar. My endocrinologist was skeptical, then surprised, and now refers people to the same protocol.

I'm one person — n=1, no control, every confounder you can name. The trials below are the reason I tried it at all. #fasting

Berberine comes up in my clinic constantly, usually as "nature's metformin." The head-to-head data is more interesting than that slogan: comparable glycemic effects in several trials, different side-effect profile, meaningful GI intolerance, and real drug-interaction concerns via CYP3A4.

I'll say the unfashionable thing in both directions: it is not a herb to wave off, and it is not a reason to stop a working prescription without supervision.