LF
Practitioner
Human study · 2 sources
Berberine and metabolic markers: what I see in clinic
Berberine comes up in my clinic constantly, usually as "nature's metformin." The head-to-head data is more interesting than that slogan: comparable glycemic effects in several trials, different side-effect profile, meaningful GI intolerance, and real drug-interaction concerns via CYP3A4.
I'll say the unfashionable thing in both directions: it is not a herb to wave off, and it is not a reason to stop a working prescription without supervision.
I'll say the unfashionable thing in both directions: it is not a herb to wave off, and it is not a reason to stop a working prescription without supervision.
Research · Randomized trial
Effect of a New Formulation of Nutraceuticals as an Add-On to Metformin Monotherapy for Patients with Type 2 Diabetes and Suboptimal Glycemic Control: A Randomized Controlled Trial.
Nutrients · 2021 · PUBMED 34371883
Research · Clinical study
The Pharmacokinetic Interaction Between Metformin and the Natural Product Goldenseal Is Metformin Dose-Dependent: A Three-Arm Crossover Study in Adults With Type 2 Diabetes
Clinical and translational science · 2025 · PUBMED 39943692